Circular letter July 2007

From Hans-Martin Hirt and Keith Lindsey, anamed international

Dear All,

Many greetings from Germany.

We have just enjoyed a four week visit of Philip Mateja from anamed in Tanzania. In the annual churches conference / assembly, Kirchentag, he worked extremely hard on the anamed stand that was inundated with many eager visitors. Even today it is still hard to convince both Africans and Europeans that a simple tea can be so effective in treating malaria, and that they can make effective medicines themselves. We were very dismayed to find that many groups at Kirchentag talked about the catastrophe of malaria and AIDS and its financial impact on communities, but very few groups had any idea about how to effectively tackle the problem with locally available knowledge, wisdom and resources.

Tragically, because of commercial orientation, chemical medicine and now even often herbal products, are having the effect of discouraging people, and making them dependent. If you are ill, you go to the doctor; if you have no money, you die. When Martin was in Tanzania, a seminar participant told him that farmers were burning their fields of artemisia as a protest because of the pitifully low price that they were being offered by the pharmaceutical industry – 50 US cents for 1 kilogram of dried leaves! We heard only today the story of a farmer in Kenya who grows artemisia for sale to industry. He asked the industrial buyer if he could himself drink the tea to treat malaria, and was immediately told that, if he did, he may die!!!

Often in Africa when we speak about “Natural Medicine”, then people associate even this with imported medicine. In Cameroon recently Martin saw that in the capital city there were innumerable Asian clinics, but in Peking there is certainly not a single African clinic! Our co-worker Bindanda M’Pia, who lives in an extremely poor district deep in the Congolese forest, was recently approached by an American company and asked if he would be willing to sell their Aloe vera products - for $100 a cure!

Wherever we go in Africa, we see that Coartem, produced by Novartis, is unaffordable for the majority of the population in Sub-Saharan Africa. Then recently in the news we read that the Chief Executive of Novartis is the top earner amongst European industrialists – with a salary of over 20 million Euros per year. (Note: Since writing this we have been reminded that in 2001 Novartis made an agreement with the WHO to supply Coartem to public sector agencies on a “not for profit” basis)

These experiences underline the urgent need for people (e.g. anamed groups) in each country of the world who build upon the skills and resources that already exist in those countries. From the economic point of view, it is a success if you can sell expensive aloe products to a poor family surrounded by aloe plants. From a humanitarian point of view it is crazy! The same is true if a doctor refuses to allow an AIDS patient to drink artemisia tea from plants in his own garden, claiming that only ARV drugs are effective. He obviously does not know that artemisinin is patented as a biological ARV.

Annual meeting of anamed international: On Saturday 22nd September 2007 in Winnenden. All friends living within reach are warmly invited. Please see our web-site for details.

Rectal administration: According to the literature, rectal administration of isolated artemisinin is becoming more and more important in the treatment of malaria. In our recommendations we have given clear instructions of how to prepare and use enemas made from artemisia leaves. Please give us feedback if you have any experience of this, whether positive or negative. For those of you with internet access, an abstract of a recent survey of the use of rectally administered artemisinin can be read at http://jama.ama-assn.org/cgi/content/abstract/297/21/2381

Artemisia and cancer: Artemisinin is rapidly becoming an internationally accepted medicine for cancer. Here we find a situation similar to that concerning artemisinin and malaria. Pharmaceuticals are being developed and used that contain artemisinin only, in spite of the fact that Artemisia annua contains many anti-cancer components. Again, please share any experiences with us, whether positive or negative, that you have of using artemisia tea with cancer patients.

With best wishes,

Martin and Keith

 

News and information

1. A film as discussion starter.

The “Integrated Regional Information Networks” (IRIN) is part of the United Nations Office for the Coordination of Humanitarian Affairs (OCHA). Its main aim is to bridge the information gap that so often exists between decision-makers, governments, humanitarian workers and the people they are trying to help by providing accurate, reliable and impartial information.

They have a very informative web-site regarding AIDS and malaria, see www.irinnews.org

IRIN has produced a film, “Malaria: Killer number one”. This film is set in Ethiopia. It shows horrendous suffering, and shows very clearly many of the features that make the problem so severe. It is an excellent stimulus for discussion, and shows very clearly the need for

    • Good nutrition.
    • Medicines that are affordable, available and that work.
    • Qualified medical staff.
    • Bed-nets.
    • Avoiding the use of DDT.

The key question for discussion is, “How can Natural Medicine help?”

The film does not, however, state the ideal strategy: self-reliance through the cultivation of Artemisia annua anamed and its use as tea. Nor does it state the need for anamed training seminars in Natural Medicine for the entire population!

The film can be downloaded from http://www.irinnews.org/InDepthMain.aspx?InDepthId=10&ReportId=57924.

 

2. Nutrition

Over the past year we have learnt a lot about grain amaranth. Like moringa, this is an excellent grain which contains vitamins, minerals and proteins, including many essential amino acids.

With good nutrition, the immune system is massively strengthened. This is particularly important for young children, pregnant women and breast feeding mothers.

Care of AIDS patients: In previous letters, and in our books, we have emphasised the remarkable beneficial effects of artemisia tea together with moringa leaf powder. In those areas where people have failed with the cultivation of moringa, we would strongly recommend grain amaranth (seeds and leaves). Keith has met groups in both Uganda and Zimbabwe who speak extremely positively about this.

3. Research into Artemisia tea as a treatment for malaria – an opportunity for you?

A consortium of UNICEF/UNDP/World Bank/WHO has a Special Programme for Research and Training in Tropical Diseases (TDR). This group is inviting applications for funding for research.

If you are

  • in what is described as a “least developed county”, and
  • in permanent employment, and
  • interested in conducting a rigorous study into the use of artemisia tea to treat malaria,

there is the possibility of receiving funding from this consortium. Such research would be of enormous benefit to all those of us, who, scattered throughout the tropical world, have committed ourselves to enabling people even in the remotest regions to become so much more self-reliant in the treatment of malaria. For more information, see http://www.who.int/tdr/grants/grants/rtg2008.htm.

4. The economics of malaria

The following is an excerpt from an article by Oliver Tickell entitled “Drugs, fakes and parasites”. It describes the work of Nick White, Professor of Tropical Medicine at Oxford University in the UK, who lives and works in Thailand. See “Oxford Today”, Volume 19 Number 1, Michaelmas 2007. The first part of the article describes the enormous problem of fake drugs, particularly in Asia. Yet another reason for encouraging self-reliance through the use of artemisia tea! Then the article makes the following observation regarding the cost of malaria, and the cost of tackling the problem comprehensively:

    'Artesunate gives us an opportunity to eradicate malaria worldwide, just as we once had the same opportunity with chloroquine. We must seize it or the danger is that it will be squandered, that resistance to the artesunate will establish and spread, and millions upon millions of people will die needlessly all because the world chose to sit back and let it happen.'

    He strongly supports the revolutionary 2004 report of the US National Academy of Sciences, 'Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance'.

    'The key finding is that the entire cost of making ACT drugs should be financed by international institutions at a cost of US$300-500 million a year', says White. 'Another $500 million or so would be needed for other measures such as insecticidal mosquito nets, as well as further research and monitoring - so that if resistance to any of the ACT drugs emerges, the therapy can be quickly reformulated in that area. The entire programme to eradicate malaria over ten years or so would cost approximately $1 billion a year - roughly the cost of ten F35 fighters. And it is not just doctors calling for this, but economists too: malaria costs Africa's economy $12 billion a year in lost production so the investment makes excellent economic sense as well as saving lives.'

We would be interested to see a calculation of the cost of treating malaria through Sub-Saharan Africa, or indeed throughout the Tropics, with artemisia tea, and of the appropriate training that this would require.

The Natural Chemotherapeutic Research Laboratory in Kampala is studying the prophylactic properties of Artemisia annua. Preliminary results indicate that drinking artemisia tea once a week could reduce malaria by 80%.

Gebeyaw Tiruneh conducted research into the widespread use of Artemisia annua anamed tea to treat malaria in Arba Minch, Ethiopia. In his thesis, he comments “Researchers at the Chinese institute of material medicine found a region of China that reported no malaria cases, and when they investigated, they discovered that people drank a tea of Artemisia annua at the first sign of malarial symptoms.” What do you think about that?

5. Campaign against the use of DDT.

Uganda is one of many countries which is considering using the insecticide DDT to control mosquitoes.

We in anamed are strongly opposed to the use of DDT. To our dismay, even the WHO has approved the use of DDT. We quote, “WHO is now recommending the use of indoor residual spraying (IRS) not only in epidemic areas but also in areas with constant and high malaria transmission, including throughout Africa.”. See http://www.who.int/mediacentre/news/releases/2006/pr50/en/index.html

In Uganda Monik Adriaens spearheaded a campaign against its use. She and her colleagues have prepared an excellent document. The following are excerpts.

In the conclusion she writes:

“This document is a compilation of scientifically proven methods already used to reduce malaria. All have significant effect on killing or repelling Anopheles larvae, mosquitoes or Plasmodium. The WHO is proposing Integrated Vector Control, in other words, a combination of one or more vector control methods. We believe in a holistic approach where all stakeholders have to take their responsibility in such a way that environment, health and economy are not compromised.”

Impacts of DDT

Toxicological effects of DDT

  • Acute toxicity: DDT is moderately to slightly toxic in studied mammalian species taken orally.
  • Chronic toxicity: DDT has caused chronic effects on the nervous system, liver, kidneys and immune system in experimental animals.
  • Reproductive effects: There is evidence that DDT causes negative reproductive effects in test animals and humans. (Pubmed Dec 2006, Aneck-Harn, Schulenburg, Bornman, De Jager)
  • Teratogenic effects: There is evidence that DDT causes teratogenic effects in test animals as well.
  • Mutagenic effects: The evidence for mutagenicity and genotoxicity is contradictory. However, in humans, blood cell cultures of men occupationally exposed to DDT showed an increase in chromosomal damage.
  • Carcinogenic effects: The evidence regarding the carcinogenicity of DDT is equivocal.
  • Organ toxicity: Acute human exposure data and animal studies reveal that DDT can affect the nervous system, liver and kidney.
  • Fat in humans and animals: DDT is very slowly transformed in animal systems.
  • Ecological effects of DDT
  • Effects on birds: DDT may be slightly toxic to almost non-toxic in birds.
  • Effects on aquatic species: DDT is very highly toxic in many aquatic invertebrate species.
  • Effects on other animals (non-target species): Earthworms are not susceptible to acute effects of DDT and its metabolites at levels higher than those likely to be found in the environment, but they may serve as an exposure source to species that feed on them.
  • Environmental effects of DDT
  • Breakdown in soil and groundwater: DDT is very highly persistent in the environment, with a reported half-life of between 2-15 years and is immobile in most soils. Routes of loss and degradation include: runoff, volatilisation, photolysis and biodegradation (aerobic and anaerobic).
  • Breakdown of chemical in surface water: DDT may reach surface waters primarily by runoff, atmospheric transport, drift, or by direct application (e.g. to control mosquito-borne malaria). The reported half-life for DDT in the water environment is 56 days (in lake water) and approximately 28 days in river water.
  • The main pathways for loss are volatilization, photo-degradation, adsorption to water-borne particulates and sedimentation. Aquatic organisms, as noted above, also readily take up and store DDT and its metabolites.
  • Breakdown of the chemical in vegetation: DDT does not appear to be taken up or stored by plants to a great extent. It was not seen to be translocated into alfalfa or soybean plants, and only trace amounts of DDT or its metabolites were observed in carrots, radishes and turnips all grown in DDT-treated soils. Some accumulation was reported in grain, maize and rice plants, but little translocation occurred and residues were located primarily in the roots.
  • Stand of the Business Community of Uganda

On 25 April 2006 a letter of the Ugandan Business Community (signed by 36 key from the dairy, honey, coffee, tea, fish, flower, textile, horticulture, and organic sector) went to the president of Uganda.

“The business community has major concerns about the plans of the government to use DDT for Controlled Indoor Spraying because it is not an effective and realistic option and a threat to the economy of Uganda. Besides, funding has been provided to Uganda for control measures known as “combination therapy” that can be effective without the use of DDT. The key reasons for the business communities concern are:

  • There is no such thing as “controlled” indoor spraying and so DDT effluents will at one point end up in the environment and the food chain and therefore negatively impact on Uganda's export markets. The stigma that would be attached to Uganda export products will affect all export sectors (flower, fish, oil seeds, coffee, tea, fruits, rice, dairy products, beef products, cotton, organic products, honey etc)
  • Malaria parasites build up resistance to DDT and the control of the adult form does not control the breeding places (the source of infection!)
  • There are enormous and collaborative funds provided from the USA and the EU for East African governments to fight malaria without the use of DDT. Uganda should follow the example of Tanzania and Zanzibar where the government concentrates on environment friendly preventive and alternative methods.

Conclusion

Malaria is the number one killer disease in Uganda and all efforts have to be put together to decrease the number of malaria victims.

DDT is not the answer to eradicate malaria. Many people still think that DDT can be used massively, as it was in the 60’s, but this method of application is now completely forbidden under the Stockholm convention. DDT in indoor residual spraying (IRS) can suppress malaria in the short term, but also has a lot of negative impacts:

First for exports: There is no way to avoid DDT contamination of the agriculture products produced by small farmers where the products have been stored in sprayed rooms. Large scale Agricultural Industries and fisheries will become affected as DDT used in IRS finds its way into the environment. Once in the environment DDT will remain for many years preventing no establishment of the export markets. Regulations are very strict when it comes to pesticide residues in food in Europe, America, Japan and many other countries.

Secondly, countries become dependant on DDT and have to spray every year otherwise malaria increases immediately the day spraying is stopped.

Thirdly, DDT is a lazy solution and does not encourage people to protect themselves and take full responsibility for their lives, due to the belief that DDT will eradicate malaria.

The last, DDT is harmful for environment, animals and human beings. It persists and accumulates in the food chain leading to problems in the nervous system and foetal development.

Therefore it is recommended that the following combination of methods should be used to fight malaria without DDT:

  • Introduction of aquatic plants such as Azolla caroliniana [Mosquito Fern], which covers the whole water surface and thereby interferes with mosquito oviposition, larvae, pupae.
  • Changes in the placement and structure of human habitations, as well as changes in behaviour, to reduce human-vector contact.
  • Education: If people don’t see the link between malaria and mosquitoes, then no steps and efforts will be undertaken to make their homes and communities mosquito-free.
  • Environment management: If, through environment management methods, 70% of man-made Anopheles mosquitoes breeding places were destroyed so that the mosquito couldn’t use them for breeding, then we could deduct (through a simple theoretical mathematic calculation) that there should be 70% fewer mosquitoes and 70% reduction in malaria occurrence!!!!
  • Use of Insecticide Treated Bednets (ITNs):
  • Studies in Ghana, Gambia, Kenya and Tanzania found that ITNs reduced child illness by 29% to 63% and child mortality by 17% to 63%, depending on net coverage and malaria transmission pressure.
  • A high percentage coverage of ITNs of all members of malaria endemic communities is considered to be the most effective way of providing protection for highly malaria vulnerable children and pregnant women (Curtis 2005). ITNs are as effective as IRS in preventing malaria
  • IRS: Experience concerning the long-term use of IRS by organized antimalaria campaigns, in many parts of the world, has frequently shown a progressive development of people’s fatigue and an increasing reluctance to allow intrusion into their homes by IRS applicators. For IRS to be successful it needs a high coverage. Both indicators make IRS success a more risky consequence.
  • Other insecticides for IRS other than DDT: Different insecticides have been proposed by different private companies working in Uganda. Some of those are:
  • Mosquiron 100®: proposed by Mr. Kirpichinikove of BALTON Kampala (2005)
  • Deltametrine: used by KOnet to treat the bed nets, Kampala 2005
  • Synthetic Pyrethroid: proposed by CHEMIPHAR Kampala 2005
  • Natural Pyrethrum: Pylarvex™, Pymos™ and Pynet™: Pyrethrum Board of Kenya
  • Fendona®: In the New Vision of 21 June 2006: “Fendona® is one of the WHO’s 12 chemicals recommended for IRS
  • Use of Pyrethrins for IRS: Pyrethrins are currently rated as the safest alternatives to DDT because they are biological products.
  • Mosquito traps: Too little research has been carried out on the Anopheles mosquito. In Europe mosquito traps are one of the most efficient methods to get rid of mosquitoes.
  • Larval control:
  • The advantages of biological larval control agents, in comparison with chemical controls, can include their effectiveness at relatively low doses, safety to humans and non-target wildlife, low cost of production, and lower risk of resistance development.
  • Fish may be particularly useful in controlling malaria vectors when associated with paddy rice fields.
  • Paris green: Historically, the most effective campaign against African vectors is the eradication of, the accidentally introduced, Anopheles gambiae from 54 000 km2 of habitat in Brazil, in the 1930s and early 1940s. This outstanding success was achieved through an integrated programme, but relied overwhelmingly upon larval control.
  • In many experiments Bti (Bacillus) killed all mosquito larvae and stopped all larval growth for 45 days. Bti does not have significantly harmful effects on beneficial insects, fish and plants. The microbial larvicides do not persist or accumulate in the environment or in body tissues and are not toxic to vertebrates and non-target aquatic organisms (WHO 1999b). Therefore, these microbial products can be safely added to drinking water used for humans and livestock and in environmentally sensitive areas.
  • Metarhizium anisopliae: Inert fungal spores that are impregnated on cloths, or sprayed on house walls or ceilings. When a mosquito touches the spores, the fungus germinates, penetrating the mosquito and grows within it. The mosquito succumbs to the fungus before it has begun to transmit malaria. Edinburgh University and Imperial College discovered that fungal infection reduced malaria transmission in the laboratory by 98%.
  • Plants with Larvicidal activities: A whole range of plants have Larvicidal activities that kill Anopheles larvae and have been tested in Laboratories. Neem (Azadirachta indica) oil and other commercial preparation of Neem have also been found as potential mosquito larvicides, stopping emergence for about 45 days. Application of 5% Neem oil-water emulsion @ 50 ml/m² in pools and @ 100 ml/ m² in tanks resulted in 100% reduction of III and IV instar larvae of An. stephensi after 24 h.
  • The adult male spider called Evarcha culicivora, feeds indirectly on vertebrate blood by actively choosing as its prey the blood-carrying female Anopheles mosquitoes that has itself been feeding on human and kills it.
  • Repellents:
  • Phytochemicals obtained from a huge diversity of plant species are safe and biodegradable. These could be screened and tested for mosquito repellent and insecticidal activities.
  • The smoke of burning Neem leaves is used for the protection against mosquitoes.
  • Neem cream provides 67 to 100% protection against malaria mosquitoes. Application of Neem oil is safe and, can be used as a personal protection measure against mosquito bites.
  • Essential oils of Cymbopogon martini, C. citratus and C. nardus provided more than 95% protection against An. culicifacies during a whole night using human baits.
  • Thermal expulsion, i.e. putting leaves or branches on a clay plate or pot without water on a small fire gave better results. It is also healthier than direct burning and gave Corymbia citriodora (lemon Eucalyptus with lemon sent) 74.4%, Lantana camara 42.4%, Lippia uckambensis 45.9%, Ocimum americanum 43.1%, O. kilimandscharicum 52 %, and O. suave 53.1% repellency.
  • Ocimum americanum, Lantana camara and Lippia uckambensis repel An. gambiae mosquitoes (with an average of 39.7 and 32.4% protection)
  • Treatment:
  • Some of the recognized plant based medicines for malaria are: Cinchona bark, Artemisia annua, Neem, Malarial (Mali, is a mixture of three plants), Ayush-64 is a drug marketed throughout India and, Cryptolepis sanguinolenta, marketed under the name of “Phyto-laria®” in Ghana
  • ANAMED, a German NGO, has long experience with :Cymbopogon citratus (Lemon grass), Allium sativum (Garlic), Zingiber officinalis (Ginger), Psidium guajava (Guava), Carica papaya (Pawpaw), Cassia occidentalis, Azadirachta indica (Neem), Vernonia amygdalina (Bitter leaf), Cinchona officinalis (Quinine) and Artemisia annua (Annual Wormwood)
  • Artemisia annua (Annual Wormwood) is currently one of the most effective herbal anti malaria drugs. A plant that every one can cultivate in mosquito prevalent areas and is inexpensive.
  • Preventive anti malaria drugs: “Preventive is better than cure”
  • Artemisinin-based therapy for prevention: In Senegal children were given every month one dose of ACT. After 13 weeks, the number of cases of clinical malaria in the group that had received treatment had fallen by 86% compared to the placebo group.

 

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